Denise began working with One Yellow Rabbit in 1983 and became Associate Artist and a permanent member of the Ensemble in 1986. She has created or co-created several shows including The Erotic Irony of Old Glory, Touch, Breeder, So Low, Permission, Featherland, Sign Language, Heavens to Murgatroid, A Fabulous Disaster, Smash Cut Freeze, and wag. In 1997, Denise created the Summer Lab Intensive and as Director continues to welcome a broad range of established and emerging artists from all over the world. She continues to teach, provide master classes, and lecture across Canada and abroad. Recently Clarkeperformed and taught as part of the Jarna Festival Academy in Sweden and created the choreography for the Canadian Opera Company’s Hadrian.
On December 30th, 2013, Denise was appointed as a Member to the Order of Canada, one of Canada's highest civilian honours. Prior to this appointment, she was also recognized by the University of Calgary with an Honourary Doctorate from the Faculty of Arts.
In 2018 Denise wrote and launched The Big Secret Book, An Intense Guide To Creating Performance Theatre.